AFRICON is an IEEE Region 8 flagship conference on the African continent. IEEE AFRICON 2021 was held in Arusha, Tanzania, 13 – 15 September 2021. The conference was co-sponsored by IEEE Region 8, the  IEEE Tanzania Sub-section and Nelson Mandela African Institution of Science and Technology. Topics covered included the full area of IEEE, e.g., Communications, Networks, Electronics, Power and Energy, Mobile Computing, Cloud Computing, Industrial Applications,  Artificial Intelligence, Nanotechnology, and E-learning. The conference featured world-class plenary speakers, major technical symposiums, industry and academic panels, workshops, tutorials and invited tracks.